Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to damaging stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it tries to repair itself before the harm was achieved. Moriarty Chiropractic is never shocked at what the body can do! Moriarty Chiropractic sees its Nashua chiropractic care as the body’s partner in healing especially when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to take care of the body. Melatonin is one nutritional tool that is proving value by interrupting the inflammatory process related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are related to intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body controls itself down to the cellular level via autophagy, the natural process via which the body’s cells clear out damaged (ie, by inflammation) or unneeded parts. In a recent study, melatonin increased autophagy and decreased the degradation of the disc’s extracellular matrix (technically marked by a decline in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin inhibits intervertebral disc degeneration by promoting autophagy. (3) Wow. Moriarty Chiropractic is inspired by this research to see just how well melatonin can work for Nashua back pain related to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition seen at Moriarty Chiropractic making positive news like this quite rousing. A new study stated that melatonin could modulate the extracellular matrix of the disc remodeling process started by IL-1 β. Additionally, melatonin reduced the inflammatory cell collection and reduced the release of connected inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin interrupted the IL-1B feedback loop, researchers suggested that melatonin may support the healing process of intervertebral discs after damage was already present. (1) Moriarty Chiropractic continues following the new research on the role inflammation has in Nashua disc degeneration and melatonin’s role in combatting it.
INFLAMMATION AND MELATONIN
The importance of melatonin in helping to slow or stop painful conditions due to inflammation is rising. The description of melatonin as a multitasking molecule influencing mood, immunity, and energy among other mechanisms is quite apropos. It is also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) activities. (1) Melatonin’s specific influence on inflammation and disc degeneration is most attention-getting to Moriarty Chiropractic and our Nashua back pain patients.
CONTACT Moriarty Chiropractic
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management handles disc degeneration for relief of chronic low back pain in her patient.
Schedule your Nashua chiropractic appointment with Moriarty Chiropractic now. We can discuss how inflammation affects your back pain and how melatonin may help with the related disc degeneration.